MechanismsHumans
Microglial reactivity attenuates ptau ₂₃₁ ‐related amyloid accumulation in preclinical Alzheimer’s disease
AAIC 2025 Abstract
Abstract
Background: Recent studies indicate that soluble tau phosphorylated at threonine 231 ( p ‐tau ₂₃₁ ) rises most prominently in the earliest preclinical stages of Alzheimer’s disease (AD), preceding overt amyloid‐beta (Aβ) PET positivity.
The paper
Wiesje Pelkmans, Mahnaz Shekari, Armand González Escalante, Gemma Salvadó
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Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Kaj Blennow, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez‐Calvet,Pasqual Maragall Foundation · Lund University
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
