Mitophagy inducing compound

1. Mitophagy inducing compound improves spatial learning and memory in mice.

   “At 15 months, MIC diet also improved spatial learning and memory in aged NonTg controls”

   AnimalsNonTg controls

   A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice

   GeroScience·6 Mar 2026

1. Mitophagy inducing compound improves working memory in mice.

   “in younger 8 month-old 3xTgAD mice, MIC restored working memory performance to NonTg levels”

   Animals3xTgAD mice

   A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice

   GeroScience·6 Mar 2026

1. Mitophagy inducing compound has no effect on amyloid-beta in mice.

   “although Aβ burden remained unchanged”

   Animals3xTgAD micebrainfrom age 4 months until 20 months on alternating weeks

   A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice

   GeroScience·6 Mar 2026

More on Amyloid-beta

1. Mitophagy inducing compound decreases microglial reactivity in mice.

   “3xTgAD mice fed an MIC-supplemented diet had a significant reduction in pTau accumulation and microglial reactivity”

   Animals3xTgAD micebrainfrom age 4 months until 20 months on alternating weeks

   A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice

   GeroScience·6 Mar 2026

More on Microglial reactivity

1. Mitophagy inducing compound decreases phosphorylated tau in mice.

   “3xTgAD mice fed an MIC-supplemented diet had a significant reduction in pTau accumulation”

   Animals3xTgAD micebrainfrom age 4 months until 20 months on alternating weeks

   A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice

   GeroScience·6 Mar 2026

More on Phosphorylated tau