Metabolic syndrome score

1. Caloric restriction decreases metabolic syndrome score in humans (-2.2).

   “healthspan (Metabolic Syndrome Score) improved in the CR arms (traditional -2.2, P < 0.01; adaptive -1.8, P = 0.02)”

   Human trialcompared to controltraditional24-weekn = 70

   Piloting Novel Nutritional Interventions for Mechanistic Studies of Human Aging · GSA 2025 abstract · 31 Dec 2025

Caloric restriction →

1. Metabolic syndrome score improves CVD risk discrimination in humans (ΔC-statistic 0.017, 95% CI 0.006-0.029).

   HumansAdding metabolic syndrome score to CKM stage in Chinese adults with CKM stages 0-3Median 7.0-year follow-upn = 7,889

   Metabolic syndrome score and cardiovascular disease risk in adults with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study · Metabolism open · 24 Sep 2026

1. Metabolic syndrome score is associated with heart disease in humans (HR 1.119).

   HumansChinese adults with CKM stages 0-3 and no baseline CVDMedian 7.0-year follow-upn = 7,889

   Metabolic syndrome score and cardiovascular disease risk in adults with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study · Metabolism open · 24 Sep 2026

Heart disease →

1. Metabolic syndrome score is associated with stroke in humans (HR 1.333).

   HumansChinese adults with CKM stages 0-3 and no baseline CVDMedian 7.0-year follow-upn = 7,889

   Metabolic syndrome score and cardiovascular disease risk in adults with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study · Metabolism open · 24 Sep 2026

Stroke →

1. Metabolic syndrome score is associated with cardiovascular disease in humans (HR 1.223, 95% CI 1.143-1.308 per 1-point higher score).

   HumansChinese adults with CKM stages 0-3 and no baseline CVD; adjusted for CKM stagePer 1-point higher scoreMedian 7.0-year follow-upn = 7,889

   Metabolic syndrome score and cardiovascular disease risk in adults with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study · Metabolism open · 24 Sep 2026

Cardiovascular disease →

1. Metabolic syndrome score lowers the risk of Parkinson's disease in humans (adjusted OR 0.71, 95% CI: 0.52–0.95).

   Humansin Chinese womenfemales

   Metabolic Syndrome and Parkinson‘s Disease in Chinese Women: Menopausal Status as an Effect Modifier · Research Square · 27 Aug 2026 · Preprint

Parkinson's disease →