Aging Cell
Growth signaling raises inflammatory gene activity in old mice
In 27-month-old mice, sustained growth signaling increased inflammatory gene activity, which five months of dietary rapamycin did not suppress.In 27-month-old mice, sustained growth signaling increased inflammatory gene activity, which five months of dietary rapamycin did not suppress.
Mouse studymTOR signaling
Who was studiedAged female and male mice, 5 months, against age-matched control mice
What changedInflammatory gene activity was higher in aged Depdc5 knockout mice than in age-matched controls
The catchDepdc5 knockout could raise inflammation through effects independent of mTORC1