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DEPDC5

Gene

2 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Cancer Prevention and Research Institute of Texas and 1 more
  • Animals1
  • Cells1

Effects

1

Triglyceride

upin mice1

1 study

  1. DEPDC5 increases triglyceride in mice.

    “Lipidomic analysis showed an increase in triglycerides (TGs) in KO mice.”

    AnimalsDEPDC5 muscle-specific knockoutskeletal muscle

    Constitutively active mTORC1 signaling modifies the skeletal muscle metabolome and lipidome response to exercise

    Journal of applied physiology (Bethesda, Md. : 1985)11 Apr 2025

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Upstream

1

KLHL22

downin cells1

1 study

  1. KLHL22 decreases DEPDC5 in cells.

    “the CUL3-KLHL22 E3 ubiquitin ligase promotes K48-linked polyubiquitination and degradation of DEPDC5”

    Cellsin response to amino acids

    KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

    Nature16 May 2018

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