Inflammation-related gene expression

BMAL1-YAP activity increases inflammation-related gene expression in mice.

“aging engages a previously uncharacterized BMAL1-YAP functional cooperation with enhanced binding at inflammation-related enhancers, amplifying target gene transcription.”

Animalsaged epidermisepidermis

Noncircadian BMAL1-YAP activity amplifies persistent inflammation in aged epidermis

Nature aging·19 Aug 2026