Triiodothyronine

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: American Physiological Society and 5 more

Animals1

Outcomes

Muscle loss

upin humans1

1 study

Triiodothyronine increases muscle loss in humans.
“excessive T3 levels, as seen in hyperthyroid states or during inappropriate replacement therapy, exacerbate catabolism and accelerate muscle loss.”
Reviewhyperthyroid states or inappropriate replacement therapy
Thyroid hormone imbalance, malnutrition, and sarcopenia: a triad of muscle health challenges
Journal of basic and clinical physiology and pharmacology14 Nov 2025

Cell viability

upin rat cells1

1 study

Triiodothyronine improves cell viability in rat cells.
“Knockdown of lncRNA showed improvement in cell viability, which was further enhanced with T3 (active TH).”
Cellswith lncRNA knockdown
Noncoding and coding mechanisms of aging-related heart failure with preserved ejection fraction associated with thyroid dysfunction
Disease models & mechanisms29 Sep 2025

Oxidative phosphorylation

upin reviews1

1 study

Triiodothyronine increases oxidative phosphorylation.
“T3 enhances mitochondrial respiration and autophagy”
Review
Thyroid Hormones and Aging: Modulators of Mitochondrial Health, Metabolic Flexibility, and Longevity Pathways
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme8 Sep 2025