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Influenza virus infection

Intervention

5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Central South University and 4 more

Outcomes

5

Neurodevelopmental gene expression

downin mice1

1 study

  1. Influenza virus infection decreases neurodevelopmental gene expression in mice.

    “Brain transcriptome analysis at three months post-infection revealed downregulation of neurodevelopmental genes”

    Animalsbrainthree months post-infection

    Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

    bioRxiv (Cold Spring Harbor Laboratory)25 Dec 2025Preprint

More on Neurodevelopmental gene expression

Inflammation-related gene expression

upin mice1

1 study

  1. Influenza virus infection increases inflammation-related gene expression in mice.

    “Transcriptomic profiling demonstrated sustained upregulation of inflammation-related genes in both lung and blood tissues, correlating with observed pathological changes.”

    Animalslung and blood

    Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

    bioRxiv (Cold Spring Harbor Laboratory)25 Dec 2025Preprint

More on Inflammation-related gene expression

Parkinsonian pathological changes

upin mice1

1 study

  1. Influenza virus infection induces parkinsonian pathological changes in mice.

    “two hallmark pathological features of Parkinson’s disease - dopaminergic neuron degeneration and Lewy body–like α-synuclein inclusions - in middle and aged infected mice.”

    Animalsbrain

    Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

    bioRxiv (Cold Spring Harbor Laboratory)25 Dec 2025Preprint

Neuronal loss

upin mice1

1 study

  1. Influenza virus infection increases neuronal loss in mice.

    “Viral infection led to substantial neuronal loss in key brain regions of mice (hippocampal CA1, CA3, and striatum) during middle and old age.”

    Animalshippocampal CA1, hippocampal CA3, striatum

    Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

    bioRxiv (Cold Spring Harbor Laboratory)25 Dec 2025Preprint

Persistent multi-organ damage

upin mice1

1 study

  1. Influenza virus infection induces persistent multi-organ damage in mice.

    “Pathological analysis revealed persistent lifelong damage in multiple organs, including chronic lung inflammation and fibrosis, along with significant cardiac and renal pathology.”

    Animalslung, heart, kidney4 to 450 days post-infection

    Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

    bioRxiv (Cold Spring Harbor Laboratory)25 Dec 2025Preprint

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