Osk gene therapy
InterventionPartial reprogramming
2 papers6 findings
- 2 independent labs in 2 countries
- Funders: European Molecular Biology Organization and 4 more
- 3 of 6 findings with company ties
- Animals2
Outcomes
6Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
Osk gene therapy improves cognitive function in mice.
“engram reprogramming also recovered learning and memory capacities to levels of healthy young animals”
Animalsin aged mice and models of Alzheimer's disease
Cognitive rejuvenation through partial reprogramming of engram cells
Neuron10 Feb 2026
Neuronal hyperexcitability
downin mice1
1 study
Neuronal hyperexcitability
downin mice1
Osk gene therapy decreases neuronal hyperexcitability in mice.
“counteracted AD-typical neuronal hyperexcitability”
Animalsin models of Alzheimer's disease
Cognitive rejuvenation through partial reprogramming of engram cells
Neuron10 Feb 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Osk gene therapy decreases cellular senescence in mice.
“partial reprogramming of engram neurons-bona fide memory trace cells-by OSK-mediated gene therapy reversed the expression of senescence- and disease-related cellular hallmarks”
Animalsin aged mice and models of Alzheimer's disease
Cognitive rejuvenation through partial reprogramming of engram cells
Neuron10 Feb 2026
Epigenetic age
downin human cells1
1 study
Epigenetic age
downin human cells1
Osk gene therapy decreases epigenetic age in human cells.
“in human keratinocytes expressing exogenous OSK, we observed significant epigenetic markers of age reversal”
Cellsexpressing exogenous OSK
Cellular reprogramming1 Feb 2024
Frailty score
upin mice1
1 study
Frailty score
upin mice1
Osk gene therapy improves frailty score in mice.
“Importantly, we observed a significant improvement in frailty scores indicating that we were able to improve the healthspan along with increasing the lifespan.”
Animalssystemically delivered adeno-associated viruses, encoding an inducible OSK systemmales
Cellular reprogramming1 Feb 2024
Median remaining lifespan
upin mice1+109%
1 study
Median remaining lifespan
upin mice1+109%
Osk gene therapy extends median remaining lifespan in mice (109%).
“in 124-week-old male mice extend the median remaining lifespan by 109% over WT controls”
Animalssystemically delivered adeno-associated viruses, encoding an inducible OSK systemmales
Cellular reprogramming1 Feb 2024