There are 11 papers on hTERT expression in aging research: 2 trials and 4 observational studies in people, 2 in animals, 2 in cells.
11 papers study it42 more mention it2 findings
- Human trial2
- Humans4
- Animals2
- Cells2
Interventions
1Ridaforolimus
downin human cells1
1 study
Ridaforolimus
downin human cells1
Ridaforolimus decreases hTERT expression in human cells (mTORC1 inhibition).
“mTORC1 inhibition with rapamycin analog Ridaforolimus suppresses TRIM28 phosphorylation, hTERT expression, and cell viability.”
CellsmTORC1 inhibition
TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer
Proceedings of the National Academy of Sciences of the United States of America
Upstream
1PRKAA1
upin human cells1
1 study
PRKAA1
upin human cells1
PRKAA1 increases hTERT expression in human cells (shown by AMPKα1 knockout).
“AMPKα1 knockout cells showed decreased expression of hTERT mRNA and protein.”
Cellsshown by AMPKα1 knockout
AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase
PloS one
Latest
5 papers in 12 monthsJournal of Assisted Reproduction and Genetics
Age-related changes in mitochondrial markers and telomere dynamics during initial growth of human preantral follicles
Cross-sectional study of 21 peopleTelomerase and telomere maintenance
Nutrients
The Impact of Ten Days of Periodic Fasting on the Modulation of the Longevity Gene in Overweight and Obese Individuals: A Quasi-Experimental Study
Non-randomized trial in 36 peopleOverweight
World Journal of Stem Cells
Expansion of human umbilical cord derived mesenchymal stem cells in regenerative medicine
Experiments in human cellsInterventions
Mayo Clinic Proceedings
Artificial Intelligence-Derived Electrocardiogram Assessment of Cardiac Age and Molecular Markers of Senescence in Heart Failure
Cohort study of 17 peopleHeart failure
Psychiatric Genetics
Telomere length and telomerase activity of leukocytes as biomarkers of selective serotonin reuptake inhibitor responses in patients with major depressive disorder
Non-randomized trial in peopleTelomere length
PNAS
TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer
Experiments in animalsTERT
Frontiers in Immunology
Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis
Cross-sectional study in peopleCellular senescence
PLOS One
AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase
Experiments in human cellsTERT