Papers on genomic stability

481 papers19 new in 30 days

Tuesday, June 2

GeroScienceJun 2

The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data

Computational studyOvarian cancer

Paper

Monday, June 1

American Journal of Respiratory and Critical Care MedicineJun 1

D94-09 Dietary Modulation of Epigenetic Aging Related Pathways in World Trade Center-Exposed Firefighters

Non-randomized trial in peopleInterventions

Paper

Sunday, May 31

Turkish Journal of Clinical ResearchMay 31

The telomere paradox: Dual regulatory roles in aging and cancer

ReviewTelomerase and telomere maintenance

Paper

Friday, May 29

Biochemistry and Biophysics ReportsMay 29

Deletion of TOP2B promoter using CRISPR-Cas9 induces senescence in HEK 293T cells

Experiments in human cellsCellular senescence

Paper

Thursday, May 28

Stem Cell Research & TherapyMay 28

Human adipose-derived mesenchymal stromal cells in vitro expansion for regenerative applications: tracking small genetic variants reveals dynamic changes within a genetically stable framework

Experiments in human cellsMechanisms

Paper

Wednesday, May 27

BiomedicinesMay 27

Genetic Determinants of Telomere Length and Their Role in Human Disease: Molecular Mechanisms and Underrepresented Populations' Perspectives

ReviewTelomerase and telomere maintenance

Paper

Wednesday, May 13

eLifeMay 13

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

Experiments in miceSynaptic transmission

Paper

bioRxivMay 13

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

Preprint: experiments in miceApoptosis

Paper

Tuesday, May 12

Stem Cell ResearchMay 12

Comparative induced pluripotent stem cell models of young, aged, and progeroid, as a resource to study human aging trajectories

Experiments in human cellsAI & data

Paper

Wednesday, May 6

Brain and BehaviorMay 6

MicroRNA-Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

ReviewEpigenetic regulation of gene expression

Paper

Monday, May 4

AnimalsMay 4

Construction of TERT Monoallelic Knockout and TERT Overexpression of Porcine Cell Lines and Study of the Cellular Biological Characteristics

Experiments in pig cellsTERT

Paper

Friday, May 1

Medical Science MonitorMay 1

Editorial: The Quest for Biomarkers of Biological Age and Longevity Identifies Roles for Small Noncoding RNAs, Including PIWI-Interacting RNAs

CommentaryBiological age

Paper

American Journal of Respiratory and Critical Care MedicineMay 1

C29-13 Somatic Variants Rescue Bone Marrow Failure, But Not Lung Disease in Patients With Germline Variants in TINF2

Experiments in human cellsLung disease

Paper

American Journal of Respiratory and Critical Care MedicineMay 1

C29-09 Early-Life Genomic Instability Drives Premature Alveolar Aging and Emphysema: Insights From Lung Proteomic Profiling of Bronchopulmonary Dysplasia and Epithelial Type 2 Cell-Specific Progeria Model

Experiments in miceDNA damage response

Paper

Wednesday, April 29

Nature CommunicationsApr 29

SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis

Experiments in miceStem cell maintenance

Paper

Tuesday, April 28

ZenodoApr 28

Ashwagandha Withanolide-A for HSC Telomerase Protection

PreprintInterventions

Paper

Sunday, April 26

ZenodoApr 26

SIRT7 in Aging Biology: Nucleolar Deacetylase Activity, Ribosomal Homeostasis, and Genomic Stability in the Context of Cellular Senescence

Preprint: reviewCellular senescence

Paper

Saturday, April 25

Journal of Translational MedicineApr 25

Mitochondria at the heart of aging: structure, function, and failure

ReviewOxidative phosphorylation

Paper

Wednesday, April 15

Genes & DevelopmentApr 15

A dual role for cGAS in shaping cellular and organismal responses to genomic instability

Experiments in killifishDNA damage response

Paper

Saturday, April 11

PreprintApr 11

Retrotransposons as Central Integrators of Disease Outcomes: Linking Genomic Instability, Immunity, and Aging

Preprint: reviewTransposable element activity

Paper

Friday, April 10

bioRxivApr 10

ATGL-catalyzed lipid catabolism promotes DNA repair

Preprint: experiments in human cellsDNA repair

Paper

Thursday, April 9

ZenodoApr 9

The dual-counting hypothesis: Unifying the Hayflick limit and the 58-generation cloning paradox in homeotherms

Preprint: reviewMechanisms

Paper

Tuesday, April 7

Stem Cells Translational MedicineApr 7

Genomic stability of human pluripotent stem cells: advances in research and screening criteria

ReviewMechanisms

Paper

Friday, April 3

ZenodoApr 3

Topological Viscoelastic Filtering in Chromatin: A Causal Mechanism for Epigenetic Rate-Limitation

Preprint: computational studyChromatin

Paper

Wednesday, April 1

Journal of Integrative Medicine and ResearchApr 1

How old are you really? Epigenetic clocks – A narrative review

ReviewEpigenetic clock

Paper

Tuesday, March 31

ZenodoMar 31

Radiation, Genomic Vitality, and the Evolution of Consciousness: A Framework for Biological Systems Beyond Terrestrial Boundaries

Preprint: reviewMechanisms

Paper

ZenodoMar 31

Environmental Spectral Radiation as a Determinant of Biological Organisation: A Unified Framework for Genomic Vitality, Ageing, Evolution and Biodiversity

Preprint: commentaryMechanisms

Paper

Monday, March 30

International Journal of Innovative Technologies in Social ScienceMar 30

THE EVOLUTION OF CANCER RESISTANCE AS AN INSPIRATION FOR MODERN ONCOLOGY – A REVIEW

ReviewMechanisms

Paper

Sunday, March 29

ZenodoMar 29

Environmental Electromagnetic Exposure and Genomic Stability: A Testable Hypothesis in Ageing Biology

Preprint: commentaryMechanisms

Paper

Friday, March 27

Frontiers in OncologyMar 27

PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific molecular heterogeneity in the Nigerian breast cancer landscape

Cross-sectional study of 102 peoplePI3K–AKT signaling

Paper