Zenodo · Apr 26, 2026
SIRT7 in Aging Biology: Nucleolar Deacetylase Activity, Ribosomal Homeostasis, and Genomic Stability in the Context of Cellular Senescence
By Frolov A
This concise review examines the molecular mechanisms underlying SIRT7's role in biological aging, with emphasis on its nucleolar deacetylase activity, rDNA repeat stabilization, and intersection with canonical hallmarks of aging. Evidence is stratified by confidence level across in vitro, rodent, and human model systems.