Frontiers in Pharmacology
Genetic study links protein to spinal narrowing in people
Genetic analyses using two European-ancestry datasets linked higher genetically predicted levels of placental alkaline phosphatase, a protein, to greater risk of spinal…Genetic analyses using two European-ancestry datasets linked higher genetically predicted levels of placental alkaline phosphatase, a protein, to greater risk of spinal canal narrowing.
Mendelian randomizationInterventions
Who was studiedPeople of European ancestry
What changedSpinal narrowing risk was higher with genetically predicted higher ALPP levels (odds ratio approximately 1.001)
The catchOverlapping proteomic and UK Biobank samples could bias the genetic association