DHEA

1. Epinephrine has no effect on DHEA in humans.

   “infusion of epinephrine (0.10 microgram/kg/min) or norepinephrine (0.15 microgram/kg/min) for 20 min neither affected DHEA plasma levels nor the DHEA/cortisol ratio.”

   Human trial0.10 microgram/kg/min20 min

   Endocrine mechanisms of stress-induced DHEA-secretion

   Journal of endocrinological investigation·Mar 1, 1998

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1. Psychological stress increases DHEA in humans.

   “Acute psychological stress of a first time parachute jump stimulated DHEA and cortisol secretion in healthy volunteers.”

   Human trialfirst time parachute jump

   Endocrine mechanisms of stress-induced DHEA-secretion

   Journal of endocrinological investigation·Mar 1, 1998

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1. Emotional self-management program increases DHEA in humans (100 percent increase).

   “There was a mean 23 percent reduction in cortisol and a 100 percent increase in DHEA/DHEAS in the experimental group.”

   Human trialfour weeks

   The impact of a new emotional self-management program on stress, emotions, heart rate variability, DHEA and cortisol

   Integrative physiological and behavioral science : the official journal of the Pavlovian Society·Jan 1, 1998

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1. DHEA decreases inflammation in rats.

   “Results suggested that inflamm-aging was more pronounced in animals with low DHEA levels”

   Animalsin aging rats

   Environmental enrichment modulates inflammation during development in long-evans rats (Rattus norvegicus)

   Developmental psychobiology·Jun 23, 2020

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1. Adrenal cortex senescence decreases DHEA.

   “Adrenal cortex senescence describes the ageing-related decline in the normal functioning of the adrenal cortex, characterised by an alteration in the output of adrenal cortical hormones, in particular reduced secretion of dehydroepiandrosterone (DHEA) and sulfated dehydroepiandrosterone (DHEAS).”

   Review

   Adrenal cortex senescence: an ageing-related pathology?

   Journal of endocrinological investigation·Mar 25, 2025

1. Short Physical Performance Battery is associated with DHEA in humans (β = -0.004, P = 0.01).

   “short physical performance battery was negatively associated with dehydroepiandrosterone (β = -0.004, P = 0.01)”

   Humansafter controlling for age and sexn = 150

   Brief Report: Relationship Between Adiposity and Biomarkers of Aging and Frailty Among Adults Aging With HIV

   Journal of acquired immune deficiency syndromes (1999)·Dec 15, 2023

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