Cyclin D2+ p21+ macrophages
Biomarker1 paper1 finding
- Animals1
Interventions
1Senolytics
downin cells1Very low certainty
1 study
Senolytics
downin cells1Very low certainty
Senolytics decrease Cyclin D2+ p21+ macrophages in cells.
Cellsliver
A distinct p21-driven macrophage senotype accumulates during aging and liver disease · bioRxiv · 28 Sep 2026 · Preprint
Latest
1bioRxivAnimalsPreprint
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with…Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.