Cellularity

Biomarker

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bioRxiv

A compound expands the brain stem-cell pool in aged mice

In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.

Preprint: experiments in miceInterventions
arXiv

Predicted gene responses vary more with age in a computer model

A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.

Preprint: computational studyMechanisms
Journal of Translational Medicine

Some T cell responses were weaker in older COVID-19 survivors

An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older…An observational study of COVID-19 survivors aged 18–59 and 60 or older found weaker responses after inactivated vaccines and subsequent Omicron infection in older adults.

Cohort study in peopleImmune response
Journal of Neuroinflammation

Protein loss promotes age-linked brain cell activation in mice

In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.

Experiments in miceMechanisms