Collagen accumulation

Biomarker

2 papers1 finding

  • Animals1
  • Cells1

Interventions

1

Young plasma

downin rats1

1 study
  1. Young plasma decreases collagen accumulation in rats.

    “heterochronic plasma exchange attenuated collagen accumulation, suggesting reduced fibrillar matrix deposition”

    Animalsaged ratslung tissue0.5 mL30 daysmales

    Young plasma transfer enhances antioxidant defense and preserves structural integrity in aged lung tissue

    The journals of gerontology. Series A, Biological sciences and medical sciences20 Jan 2026

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Science Advances

Support cells worsened disease features in lab-grown human vessels

Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria…Experiments with three-layer vessels built from human cells found that support cells increased several vascular disease features in a model of Hutchinson-Gilford progeria syndrome.

Experiments in human cellsMechanisms
American Journal of Physiology Regulatory, Integrative and Comparative Physiology

Aged perivascular fat worsens aortic stiffness in mice

Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat collagen levels.Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat collagen levels.

Experiments in animalsMechanisms