Biological aging clocks

Biomarker

2 papers3 findings

Associations

3

Biological age

mixedin humans1

1 study
  1. Biological aging clocks are associated with biological age in humans.

    “Current evidence suggests that BACs represent distinct operationalizations of biological aging instead of interchangeable measures of a single construct.”

    Review

    Biological aging clocks as biomarkers of human aging: Biological basis, methodological design, and epidemiological implications

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion31 Aug 2026

Organ dysfunction

upin humans1

1 study
  1. Biological aging clocks are associated with organ dysfunction in humans.

    “accelerated biological aging was consistently associated with increased mortality, organ dysfunction, and post-ICU vulnerability.”

    Reviewcritical illness

    Deep Biological Clocks in Critical Care Medicine: A Scoping Review Toward Translational Precision Care

    Journal of personalized medicine4 Feb 2026

Mortality

upin humans1

1 study
  1. Biological aging clocks are associated with mortality in humans.

    “accelerated biological aging was consistently associated with increased mortality, organ dysfunction, and post-ICU vulnerability.”

    Reviewcritical illness

    Deep Biological Clocks in Critical Care Medicine: A Scoping Review Toward Translational Precision Care

    Journal of personalized medicine4 Feb 2026

Latest

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bioRxiv

Mechanistic biological age clock matches PhenoAge in predicting human mortality

The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.

Preprint: cohort study of 24,650 peoplePhenoAge
Science Advances

Speech age gaps track dementia phenotypes and biological aging

In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic aging clocks.In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic aging clocks.

Cohort study of 2,928 peopleFrontotemporal dementia
medRxiv

Biological age uncertainty independently predicts mortality and health decline in humans

Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse…Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.

Preprint: cohort study of 450,000 peopleBiomarkers