Phenotypic Age
Biomarker4 papers6 findings
- Humans4
Effects
110-meter gait time
downin humans1
1 study
10-meter gait time
downin humans1
Phenotypic Age impairs 10-meter gait time in humans (β = 0.48 seconds/year, P < 0.001).
Humansadjusted for sex, BMI, weight, frailty, diabetes, hypertensionn = 173
Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty · The Journal of arthroplasty · 15 Sep 2026
Associations
5Smoking
upin humans1Low certainty
1 study
Smoking
upin humans1Low certainty
Smoking is associated with Phenotypic Age in humans.
Humansin patients undergoing TKAn = 173
Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty · The Journal of arthroplasty · 15 Sep 2026
Alcohol
upin humans1Low certainty
1 study
Alcohol
upin humans1Low certainty
Alcohol is associated with Phenotypic Age in humans.
Humansin patients undergoing TKAn = 173
Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty · The Journal of arthroplasty · 15 Sep 2026
Symptomatic perioperative complications
upin humans1OR 1.11
1 study
Symptomatic perioperative complications
upin humans1OR 1.11
Phenotypic Age raises the risk of symptomatic perioperative complications in humans (OR = 1.11, 95% CI 1.04 to 1.19, P = 0.003).
Humansadjusted for sex, BMI, weight, frailty, diabetes, hypertensionn = 173
Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty · The Journal of arthroplasty · 15 Sep 2026
Perioperative complications
upin humans1OR 1.2
1 study
Perioperative complications
upin humans1OR 1.2
Phenotypic Age raises the risk of perioperative complications in humans (OR = 1.20 per one-year increase, 95% CI 1.10 to 1.30, P < 0.001).
Humansadjusted for sex, BMI, weight, frailty, diabetes, hypertensionn = 173
Biological Age Acceleration Predicts Functional Decline and Surgical Risk in Knee Arthroplasty · The Journal of arthroplasty · 15 Sep 2026
Mortality
upin humans1HR 1.08
1 study
Mortality
upin humans1HR 1.08
Phenotypic Age raises the risk of mortality in humans (HR = 1.080, 95% CI: 1.023-1.140).
Humansin breast cancer patientsn = 399
Prognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020 · Health science reports · 13 Sep 2026
Latest
26Faster biological aging linked to early colorectal adenocarcinoma
In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those…In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those without it.
Biological aging and heart health link to lung disease risk
A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory…A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.
Accelerated biological aging links to higher gout risk and increased mortality
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.
Lifestyle modification reduces phenotypic age in adults with prediabetes
A six-month randomized trial in Arab adults found structured diet and exercise reduced biological age alongside metabolic markers.A six-month randomized trial in Arab adults found structured diet and exercise reduced biological age alongside metabolic markers.