3 papers3 findings
Pharmacological depletion of sap/ptx2
downin mice1
Pharmacological depletion of sap/ptx2 decreases amyloid deposits in mice.
“Finally, pharmacological depletion of SAP/PTX2 from aged mice abolishes bone marrow amyloid deposition and effectively rescues the low bone mass phenotype.”
Animalsbone marrow
Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis
bioRxiv : the preprint server for biology15 Aug 2024Preprint
Insulin resistance
upin humans1
Insulin resistance increases amyloid deposits in humans.
“insulin resistance, associated with obesity, leads to amyloid deposits and plaque buildup in the brain”
Reviewassociated with obesitybrain
Chronic low‐grade Inflammation in Obesity as a Potential Biomarker for Alzheimer's Disease
AAIC 2025 abstract24 Dec 2025
APCS
upin mouse cells1
APCS increases amyloid deposits in mouse cells.
“SAP/PTX2 colocalizes with amyloid deposits around senescent BMAds in vivo and is sufficient to promote the formation of insoluble amyloid deposits from soluble Aβ peptides”
Cellsin in vitro and ex vivo 3D BMAd-based culture experiments
Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis
bioRxiv : the preprint server for biology15 Aug 2024Preprint
Japan Society for the Promotion of ScienceJP¥4.6m
In an observational study of 1,110 people, living in more deprived areas was associated with lower cognitive scores and more amyloid build-up in unimpaired brains.In an observational study of 1,110 people, living in more deprived areas was associated with lower cognitive scores and more amyloid build-up in unimpaired brains.
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.