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Pharmacological depletion of sap/ptx2

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

Outcomes

1

Amyloid deposits

downin mice1

1 study

  1. Pharmacological depletion of sap/ptx2 decreases amyloid deposits in mice.

    “Finally, pharmacological depletion of SAP/PTX2 from aged mice abolishes bone marrow amyloid deposition and effectively rescues the low bone mass phenotype.”

    Animalsbone marrow

    Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis

    bioRxiv : the preprint server for biologyAug 15, 2024Preprint

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