alpha-Klotho

1. alpha-Klotho predicts coronary atherosclerosis in humans (AUC = 0.754, 95% CI 0.654-0.855).

   “ROC analysis demonstrated moderate discrimination for the presence of coronary atherosclerosis, defined as Agatston score > 0 (equivalently, CAD-RADS > 0 in this cohort) (AUC = 0.754, 95% CI 0.654-0.855)”

   Humansserum

   Serum Alpha-Klotho and Coronary Atherosclerosis: Associations with Coronary CT Angiography Findings and Atherogenic Indices · Biomedicines · 9 Sep 2026

Coronary atherosclerosis →

1. alpha-Klotho is associated with CAD-RADS in humans (OR = 0.525, p = 0.033).

   “Klotho remained independently associated with CAD-RADS severity after adjustment for age, sex, BMI, and AIP (OR = 0.525, p = 0.033).”

   Humansadjusted for age, sex, BMI, and AIPserum

   Serum Alpha-Klotho and Coronary Atherosclerosis: Associations with Coronary CT Angiography Findings and Atherogenic Indices · Biomedicines · 9 Sep 2026

CAD-RADS →

1. alpha-Klotho is associated with Agatston score in humans (ρ = -0.540).

   “Agatston score (ρ = -0.540)”

   Humansserum

   Serum Alpha-Klotho and Coronary Atherosclerosis: Associations with Coronary CT Angiography Findings and Atherogenic Indices · Biomedicines · 9 Sep 2026

Agatston score →