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National Institute on AgingUS$332.1k

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Nature Communications

Aged human T cells briefly regain young-like patrol behaviour

In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.In laboratory experiments, thicker fluid temporarily restored young-like monitoring behaviour, particularly in a subgroup of aged human memory T cells.

Human cell studyBlood and immune system
Advanced Science

Lamin B1 deficiency impairs bone formation in stem cells

In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.In bone marrow stem cells linked to senile osteoporosis, lamin B1 loss triggered a form of cell death that disrupted mitochondria and impaired bone formation.

Experiments in cellsBones and joints
Osteoarthritis and Cartilage

Heat pulses resynchronise daily clocks in mouse cartilage

A 60-minute pulse at 43 °C resynchronised daily rhythms in cartilage explants from young and aged mice, counteracting disruption caused by an inflammatory signal.A 60-minute pulse at 43 °C resynchronised daily rhythms in cartilage explants from young and aged mice, counteracting disruption caused by an inflammatory signal.

Experiments in mouse cellsBones and joints