Trehalose

3 papers3 findings

PubChem 7427 ChEBI 140775

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

3

Superoxide dismutase

no changein rats1

1 study

Trehalose has no effect on superoxide dismutase in rats.
“superoxide dismutase (SOD) activity was reduced in the kidneys of aged rats but was not affected by trehalose intervention”
Animalsaged ratskidney2%one month
Effects of trehalose on NFE2L2, catalase, and superoxide dismutase in the kidney of aged rats
Molecular biology research communications1 Mar 2022

More on Superoxide dismutase

CAT

downin rats1

1 study

Trehalose decreases CAT in rats.
“In addition, the activity and mRNA levels of catalase (CAT) increased in aged rats while treatment with trehalose reversed this trend.”
Animalsaged ratskidney2%one month
Effects of trehalose on NFE2L2, catalase, and superoxide dismutase in the kidney of aged rats
Molecular biology research communications1 Mar 2022

NFE2L2

upin rats1

1 study

Trehalose increases NFE2L2 in rats.
“Protein levels of NFE2L2 showed a 50% reduction in aged rats compared to young rats (P<0.001), which was restored by trehalose intervention.”
Animalsaged ratskidney2%one month
Effects of trehalose on NFE2L2, catalase, and superoxide dismutase in the kidney of aged rats
Molecular biology research communications1 Mar 2022

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