Sophocarpine

2 papers2 findings

PubChem ChEBI MeSH

2 independent labs in 1 country

Funders: Jiangsu Commission of Health and 1 more

Animals2

Outcomes

2

Kidney fibrosis

downin mice1

1 study

Sophocarpine decreases kidney fibrosis in mice.
“sophocarpine ameliorates renal fibrosis and preserves function in D-galactose-induced progeroid mice by restoring autophagy”
Animalsin D-galactose-induced progeroid micekidney
LAPTM5 Promotes Age-Related Renal Fibrosis via USP10/PTEN-Mediated Autophagy Inhibition
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18 May 2026

More on Kidney fibrosis

Intestinal fibrosis

downin mice1

1 study

Sophocarpine decreases intestinal fibrosis in mice.
“SPC alleviates the inflammatory response, improves intestinal fibrosis and maintains intestinal mucosal homeostasis in vivo.”
Animalsin DSS-induced UC mice
Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis
European journal of pharmacology1 Feb 2024

Latest

1 in 12 months

FASEB Journal18 May

LAPTM5 Promotes Age-Related Renal Fibrosis via USP10/PTEN-Mediated Autophagy Inhibition

Experiments in miceKidney

bioRxiv17 Sep

Qing-Luo-Yin-induced SIRT1 inhibition contributes to the immune improvement of adjuvant-induced arthritis rats

Preprint: experiments in animalsInterventions

European Journal of Pharmacology4 Feb

Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis

Experiments in miceGut and microbiome