Aldosterone
Intervention2 papers3 findingsPubChem 5839ChEBI 27584MeSH D000450
- Animals2
Outcomes
3Cardiomyocyte proliferation
upin cells1Very low certainty
1 study
Cardiomyocyte proliferation
upin cells1Very low certainty
Aldosterone increases cardiomyocyte proliferation in cells.
“GR disruption also enhances aldosterone-induced proliferation in cardiomyocyte-enriched cultures”
Cellsin cardiomyocyte-enriched cultures
Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart · bioRxiv · 11 Sep 2026 · Preprint
Apoptosis
downin mice1Very low certainty
1 study
Apoptosis
downin mice1Very low certainty
Aldosterone inhibits apoptosis in mice.
Animalsin naturally aged micecochlea
Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging · Cellular signalling · 24 Aug 2026
Auditory thresholds
upin mice1Very low certainty
1 study
Auditory thresholds
upin mice1Very low certainty
Aldosterone improves auditory thresholds in mice.
Animalscochlea
Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging · Cellular signalling · 24 Aug 2026
Funding
National Institute of Diabetes and Digestive and Kidney DiseasesUS$770.3kNational Heart, Lung, and Blood InstituteUS$752.8k2 grants since 2016
Adrenal Origins of Aldosterone Excess
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of Michigan at Ann ArborUS$770.3k2016–2031
Aldosterone and the menopausal transition's increase in blood pressure and cardiovascular risk
National Heart, Lung, and Blood InstituteUniversity of Michigan at Ann ArborUS$752.8k2024–2029
Latest
21Klotho deficiency disrupts potassium balance in mice
In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed.