Arecoline

3 papers2 findings

PubChem 2230 ChEBI 2814 MeSH D001115

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Central South University and 1 more

Animals1
Model organisms2

Outcomes

2

Oral submucous fibrosis

upin mice1

1 study

Arecoline induces oral submucous fibrosis in mice.
“Finally, an arecoline-exposed OSF mouse model validated key in vivo aspects of this pathway, supporting its physiological relevance.”
Animalsarecoline exposure
YY1 lactylation promotes fibroblast senescence by targeting the PU.1-BTG2 axis to promote oral submucous fibrosis
Chemico-biological interactions30 Aug 2025

More on Oral submucous fibrosis

SPI1

upin human cells1

1 study

Arecoline increases SPI1 in human cells (∼3.5-fold mRNA, ∼3-fold protein).
“human oral fibroblasts were treated with 100 μM arecoline, which significantly increased the expression of the transcription factor PU.1(Purine-rich box 1) (∼3.5-fold mRNA, ∼3-fold protein).”
Cellsoral fibroblasts100 μM
YY1 lactylation promotes fibroblast senescence by targeting the PU.1-BTG2 axis to promote oral submucous fibrosis
Chemico-biological interactions30 Aug 2025

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