Decitabine
- 2 independent labs in 2 countries
- Funders: China Postdoctoral Science Foundation and 5 more
- Model organisms2
- Cells1
Outcomes
2Epigenetic age
downin mouse cells1
1 study
Epigenetic age
downin mouse cells1
Decitabine decreases epigenetic age in mouse cells (from 22 to 10 months).
“treatment with the DNA methylation inhibitor decitabine reduced the methylation age of organoids from 22 to 10 months”
Cellsin cultureintestinal organoids
Modeling age-related methylation changes in vitro with intestinal organoids
BMC biology6 Mar 2026
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Decitabine decreases cellular senescence in human cells.
“reversal of PRKAG2 epigenetic silencing with decitabine mitigated PDLSC senescence by suppressing ATM signaling.”
Cells
Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells
Journal of advanced research30 Dec 2024
Latest
3 in 12 monthsBMC Biology
Modeling age-related methylation changes in vitro with intestinal organoids
Experiments in mouse cellsBiomarkers
bioRxiv
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes
Preprint: experiments in model organismsInterventions
Journal of Orthopaedic Surgery and Research
Epigenetic silencing of SPHK1-IRF7 axis drives inflammaging in age-related meniscus degeneration via sphingolipid-immune dysregulation
Cohort study in peopleImmune response
Journal of Advanced Research
Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells
Experiments in mouse cellsTGF-β signalling