MAPT accumulation

1. Propranolol increases MAPT accumulation in mice.

   “Inhibition of β2-AR by propranolol (30 mg/kg, intragastric administration 1 h before each AE session) restrained AE-attenuated MAPT accumulation by inhibiting autophagy-lysosomal flux in MAPT P301L mice.”

   AnimalsAE-treated MAPT P301L mice30 mg/kg

   Aerobic Exercise Attenuates Autophagy-Lysosomal Flux Deficits via β2-AR-Mediated ESCRT-III Subunit CHMP4B in Mice With Human MAPT P301L

   Aging cell·26 Jul 2025

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