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PARTIAL REPROGRAMMING OF THE AGING NEUROGENIC NICHE

GSA 2024 Abstract

Abstract

Reprogramming of somatic cells by constant expression of the Yamanaka factors (Oct4, Sox2, Klf4, c-Myc) results in pluripotent stem cells and erases many hallmarks of aging in vitro.

  • Partial reprogramming
  • KLF4
  • MYC
  • POU5F1
  • SOX2
  • Mice

The paper

Xu L, Ramirez-Matias J, Hauptschein M et al.

GSA 2024 Abstract · 31 Dec 2024 · CC BY

Presented at GSA 2024

doi.org/10.1093/geroni/igae098.0870

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