Rapamycin + nicotinamide

1. Rapamycin + nicotinamide improves stem cell differentiation in human cells.

   “rapamycin, and NAM attenuated the senescence-associated changes, including decreased β-galactosidase expression, dysfunctional lysosomes, reduced total cellular ROS, and improved osteogenic differentiation.”

   Cellsin aged MSCs10 nM rapamycin + 5 mM NAMduration of a culture passage

   Rapamycin and nicotinamide treatment attenuates senescence-associated features in mesenchymal stromal cells isolated from elderly donors by modulating autophagy

   Scientific reports·30 Jun 2026

More on Stem cell differentiation

1. Rapamycin + nicotinamide decreases senescence-associated secretory phenotype (SASP) in human cells.

   “Treatment with these compounds reduced pro-inflammatory cytokines, IL-1β and IL-6.”

   Cellsin aged MSCs10 nM rapamycin + 5 mM NAMduration of a culture passage

   Rapamycin and nicotinamide treatment attenuates senescence-associated features in mesenchymal stromal cells isolated from elderly donors by modulating autophagy

   Scientific reports·30 Jun 2026

More on Senescence-associated secretory phenotype (SASP)

1. Rapamycin + nicotinamide decreases cellular senescence in human cells.

   “rapamycin, and NAM attenuated the senescence-associated changes, including decreased β-galactosidase expression”

   Cellsin aged MSCs10 nM rapamycin + 5 mM NAMduration of a culture passage

   Rapamycin and nicotinamide treatment attenuates senescence-associated features in mesenchymal stromal cells isolated from elderly donors by modulating autophagy

   Scientific reports·30 Jun 2026

More on Cellular senescence

1. Rapamycin + nicotinamide decreases CDKN2A in human cells.

   “Aged MSCs treated with rapamycin and NAM exhibited increased replicative capacity and decreased p16 and p21 expression.”

   Cellsin aged MSCs10 nM rapamycin + 5 mM NAMduration of a culture passage

   Rapamycin and nicotinamide treatment attenuates senescence-associated features in mesenchymal stromal cells isolated from elderly donors by modulating autophagy

   Scientific reports·30 Jun 2026

More on CDKN2A