Melanin

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

2 of 2 findings with company ties

Outcomes

Cellular senescence

upin human cells1

1 study

Melanin induces cellular senescence in human cells.
“induces senescence-associated phenotypes characterized by perturbed cell cycle progression, increased cell size and aneuploidy, and the secretion of inflammatory mediators in proliferating keratinocytes”
Cellsin proliferating keratinocytes
A Non-Invasive Approach to Intracellular Measurement in Solar Lentigo: Investigating Mitochondrial Dysfunction and Senescence Mechanisms Associated with Excessive Melanin Deposition
International journal of molecular sciences11 Nov 2025

Latest

9 in 12 months

Pigment Cell & Melanoma Research3 Oct

Darker skin is linked to fewer mtDNA variants from sun exposure

Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men.Photoexposed light skin possessed six-fold more variants than dark skin across paired biopsies from six older men.

Cross-sectional study of 6 peopleSkin

Paper

Ophthalmology Retina16 Sep