Ventricular arrhythmias

1. Physical activity has no effect on ventricular arrhythmias in humans.

   “No associations were observed between MVPA and risk of NICM or VA in G+P- individuals.”

   Humansin phenotype-negative carriers of cardiomyopathy-associated rare variants (G+P-)

   Effects of Device-Measured Physical Activity on Disease Progression and Cardiovascular Outcomes in Phenotype-Negative Carriers of Cardiomyopathy-Associated Rare Variants

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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1. Papillary muscle T1 is associated with ventricular arrhythmias in humans (43% increase in odds per 100 ms).

   “PM T1 (/100 ms) was significantly associated with a 39%, 22%, 31% and 43% increase in the odds of prevalent MVP/mitral regurgitation, heart failure, atrial fibrillation and ventricular arrhythmias”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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