IGF-1

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 2 more

Animals2

Outcomes

5

Senescent smooth muscle cells

downin pigs1

1 study

IGF-1 decreases senescent smooth muscle cells in pigs (19% decrease vs. control).
“depleted SMC-like senescent cells (βGal + /aSMA + cells) (19% decrease vs. control).”
Animalshypercholesterolemic pigs (FH pigs)coronary plaque fibrous cap100μg/kg/d180d
Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Senescent smooth muscle cells

Senescence-associated beta-galactosidase

downin pigs1

1 study

IGF-1 decreases senescence-associated beta-galactosidase in pigs (-62% β Gal, -68% p21).
“IGF-1 downregulated senescence markers in the plaque fibrous cap: β Gal: 62% decrease, p21: 68% decrease (all are P<0.05 vs. control)”
Animalshypercholesterolemic pigs (FH pigs)coronary plaque fibrous cap100μg/kg/d180d
Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Senescence-associated beta-galactosidase

Blood-brain barrier permeability

downin reviews1

1 study

IGF-1 inhibits blood-brain barrier permeability.
“IGF-1 may also inhibit blood brain barrier permeability”
Reviewin brain
Insulin-Like Growth Factor-1 and Neuroinflammation
Frontiers in aging neuroscience3 Nov 2017

M1 microglial phenotype

downin reviews1

1 study

IGF-1 inhibits M1 microglial phenotype.
“IGF-1 promotes the microglial M2 and inhibits of M1 phenotype”
Reviewin microglia
Insulin-Like Growth Factor-1 and Neuroinflammation
Frontiers in aging neuroscience3 Nov 2017

Inflammation

downin reviews1

1 study

IGF-1 inhibits inflammation.
“several studies revealed anti-inflammatory effects of IGF-1 acting on astrocytes and microglia”
Reviewin astrocytes and microglia
Insulin-Like Growth Factor-1 and Neuroinflammation
Frontiers in aging neuroscience3 Nov 2017

More on Inflammation

Funding

4 grants since 2023

National Institute on AgingUS$1.7mNational Institute of Neurological Disorders and StrokeUS$534.2kVeterans Affairs

Latest

1 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression

Experiments in pigsPI3K–AKT signalling

Frontiers in Aging Neuroscience3 Nov

Insulin-Like Growth Factor-1 and Neuroinflammation

ReviewInflammation

Nature Medicine1 Jul

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Experiments in miceBones and joints