Senescent smooth muscle cells

1 paper1 finding

Animals1

Interventions

1

IGF-1

downin pigs1

1 study

IGF-1 decreases senescent smooth muscle cells in pigs (19% decrease vs. control).
“depleted SMC-like senescent cells (βGal + /aSMA + cells) (19% decrease vs. control).”
Animalshypercholesterolemic pigs (FH pigs)coronary plaque fibrous cap100μg/kg/d180d
Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression
AHA Scientific Sessions 2025 abstract3 Nov 2025

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AHA Scientific Sessions 2025 Abstract3 Nov

Downregulation of Insulin-Like Growth Factor I (IGF-1) Signaling Induces Cell Senescence in Vascular Smooth Muscle Cells: Implications for Atherosclerotic Plaque Progression

Experiments in pigsPI3K–AKT signalling