Health coaching

6 papers9 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 1 country

Funders: National Heart, Lung, and Blood Institute and 1 more

Human trial4
Humans1

Outcomes

Low-density lipoprotein cholesterol

downin humans2

2 studies

Health coaching decreases low-density lipoprotein cholesterol in humans (-22.7 mg/dL).
“Mean LDL-C change from baseline was -22.7 mg/dL (Wilcoxon signed rank test, P<0.001).”
Human trialin veterans with atherosclerotic cardiovascular diseasen = 152
A Health Coach-Based Multilevel Personalized Strategy Lowers Low-Density Lipoprotein Cholesterol and Enhances Lipid Control in Veterans With Atherosclerotic Cardiovascular Disease
Journal of the American Heart Association9 Sep 2026
Health coaching decreases low-density lipoprotein cholesterol in humans (-25.5 vs. -14.7 mg/dL).
“Veterans who worked with a HC saw greater improvements in statin + additional LLT use (15% vs. 7%), LLT adherence (24% vs. 14%), percent meeting LDL-C goal <70mg/dL (40% vs. 31%), and mean LDL-C (-25.5 vs. -14.7 mg/dL).”
HumansASCVD and baseline LDL-C ≥ 70 mg/dL12 monthsn = 2,093
Twelve-month Changes in Lipid Management among Veterans who worked with a Health Coach vs. those who did not in the Veterans Affairs Lipid Optimization Reimagined Quality Improvement (VALOR-QI) Program
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Low-density lipoprotein cholesterol

Low-density lipoprotein cholesterol control

upin humans1+43%

1 study

Health coaching increases low-density lipoprotein cholesterol control in humans (42.6%).
“The proportion with controlled LDL-C was 42.6% (binomial test, P=0.001).”
Human trialin veterans with atherosclerotic cardiovascular diseasen = 152
A Health Coach-Based Multilevel Personalized Strategy Lowers Low-Density Lipoprotein Cholesterol and Enhances Lipid Control in Veterans With Atherosclerotic Cardiovascular Disease
Journal of the American Heart Association9 Sep 2026

Statin + additional LLT use

upin humans1

1 study

Health coaching increases statin + additional LLT use in humans (15% vs. 7%).
“Veterans who worked with a HC saw greater improvements in statin + additional LLT use (15% vs. 7%), LLT adherence (24% vs. 14%), percent meeting LDL-C goal <70mg/dL (40% vs. 31%), and mean LDL-C (-25.5 vs. -14.7 mg/dL).”
HumansASCVD and baseline LDL-C ≥ 70 mg/dL12 monthsn = 2,093
Twelve-month Changes in Lipid Management among Veterans who worked with a Health Coach vs. those who did not in the Veterans Affairs Lipid Optimization Reimagined Quality Improvement (VALOR-QI) Program
AHA Scientific Sessions 2025 abstract3 Nov 2025

Medication adherence

upin humans1

1 study

Health coaching increases medication adherence in humans (baseline = 86%, 12-week = 100% adherence).
“Medication adherence: baseline = 86%, 12-week = 100% adherence.”
Human trial12 weeksn = 49
ADRD RISK REDUCTION HEALTH COACHING
GSA 2024 abstract31 Dec 2024

Alcohol consumption

downin humans1

1 study

Health coaching decreases alcohol consumption in humans (baseline mean = 1.50/week, 12-week = 1.10/week).
“Alcoholic Drinks: baseline mean = 1.50/week, 12-week = 1.10/week”
Human trial12 weeksn = 49
ADRD RISK REDUCTION HEALTH COACHING
GSA 2024 abstract31 Dec 2024

Smoking

downin humans1

1 study

Health coaching decreases smoking in humans (baseline mean = 0.62/day, 12-week = 0.30/day).
“Cigarettes: baseline mean = 0.62/day, 12-week = 0.30/day”
Human trial12 weeksn = 49
ADRD RISK REDUCTION HEALTH COACHING
GSA 2024 abstract31 Dec 2024