Lifespan
downin B. mori1is required forin worms1
Dopamine shortens lifespan in B. mori.
“Reducing dopamine levels shortened lifespan”
Model organismsreducing dopamine levels
Insects14 Feb 2026
Dopamine is required for lifespan in worms.
“Touch modulation of dietary restriction requires putative mechanoreceptor proteins, the neurotransmitters dopamine and tyramine/adrenaline, and the neuropeptides INS-11 and GnRH.”
Model organismsfor touch modulation of dietary restriction
Rewarding touch limits lifespan through neural to intestinal signaling
Proceedings of the National Academy of Sciences of the United States of America23 Oct 2025
Oxidative stress and ROS signalling
downin B. mori1
Dopamine protects against oxidative stress and ROS signalling in B. mori.
“lifespan-extending effect of dopamine was closely correlated with enhanced total antioxidant capacity”
Model organismsmoderate peripheral administration or elevated endogenous levels
Insects14 Feb 2026
Locomotor activity
upin B. mori1
Dopamine improves locomotor activity in B. mori.
“improved locomotor activity, and restored motor vigor in aged moths”
Model organismsmoderate peripheral administration
Insects14 Feb 2026
Healthspan
upin B. mori1
Dopamine improves healthspan in B. mori.
“moderate peripheral administration significantly extended healthspan, improved locomotor activity, and restored motor vigor in aged moths”
Model organismsmoderate peripheral administration
Insects14 Feb 2026
In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo.In a 52-week randomised trial, disease rating scores rose by 2.45 points with the supplement compared with a 0.27-point fall with placebo.
In 3,650 adults, elevated modeled dopamine clearance was linked to poorer cognition only with marked structural degradation and within sliding age windows centered…In 3,650 adults, elevated modeled dopamine clearance was linked to poorer cognition only with marked structural degradation and within sliding age windows centered between 56 and 76 years.
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.