Diesel exhaust particles
1 paper3 findings
- 1 lab in 1 country
- Funders: National Foundation for Medical Research and Innovation and 1 more
- Humans1
Outcomes
3NF-κB signalling
upin human cells1
1 study
NF-κB signalling
upin human cells1
Diesel exhaust particles activate NF-κB signalling in human cells.
“NF-κB p65 nuclear translocation, observed at 24 hours, highlighted its critical role in cytokine release and inflammation following exposure to DEP and WFSE.”
Cellsmonocyte-derived microglia-like cells24 hours
Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia
bioRxiv (Cold Spring Harbor Laboratory)20 Dec 2024Preprint
TNF-α, IL-6, IL-23, and IL-33 secretion
upin human cells1
1 study
TNF-α, IL-6, IL-23, and IL-33 secretion
upin human cells1
Diesel exhaust particles increase TNF-α, IL-6, IL-23, and IL-33 secretion in human cells.
“DEP induced a rapid response, increasing TNF-α, IL-6, IL-23, and IL-33 within 2 hr in young MDMi and 24 hr in aged MDMi.”
CellsCells derived from healthy individualsmonocyte-derived microglia-like cellsWithin 2 hours in young MDMi and 24 hours in aged MDMi
Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia
bioRxiv (Cold Spring Harbor Laboratory)20 Dec 2024Preprint
HMOX1
upin human cells1
1 study
HMOX1
upin human cells1
Diesel exhaust particles increase HMOX1 in human cells.
“DEP and WFS extract (WFSE) significantly upregulated expression of the oxidative stress marker, heme-oxygenase-1 (HO-1) in MDMi after 24 hr”
Cellsmonocyte-derived microglia-like cells24 hours
Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia
bioRxiv (Cold Spring Harbor Laboratory)20 Dec 2024Preprint