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CIRCATXN1 sirna-tfna

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

1

Intervertebral disc degeneration

downin mice1

1 study

  1. CIRCATXN1 sirna-tfna prevents intervertebral disc degeneration in mice.

    “administering an aging cell-adapted siRNA nucleic acid framework delivery system to progerin pathologically expressed premature aging mice (zmpste24-/-) can ameliorate the cellular matrix in the nucleus pulposus tissue, effectively delaying IVDD.”

    Animalsin zmpste24-/- micenucleus pulposus tissue

    Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization

    Research (Washington, D.C.)23 Mar 2024

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