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HNRNPA2B1

Gene

4 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: National Cancer Institute and 3 more
  • Humans1
  • Animals3

Effects

1

Neurotoxicity

upin flies1

1 study

  1. HNRNPA2B1 increases neurotoxicity in flies.

    “computationally predicted and experimentally demonstrated how HNRNPA2B1 and MEPCE enhance tau-mediated neurotoxicity.”

    Model organismstau-mediated neurotoxicity

    An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration

    bioRxiv : the preprint server for biology9 Oct 2024Preprint

Associations

1

Lifespan

upin humans1

1 study

  1. HNRNPA2B1 is associated with lifespan in humans.

    “Two splicing regulators, HNRNPA1 and HNRNPA2B1, were also associated with parental longevity in humans, in the InCHIANTI aging study.”

    Humans

    Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

    Aging cell30 Jun 2016

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