Apolipoprotein B
Apolipoprotein B has been studied in 20 papers since 2016: 20 observational studies in people; 4 in the past year. The newest paper, Jun 17, 2026: “Association of the apolipoproteins with retinal arteriosclerosis in a health examination population”.
20 papers study it16 findingsUpdated
See all 20 papers on apolipoprotein B
At a glance
The findings reach people, from one lab or study. 12 independent labs in 6 countries.
“Conversely, those in the highest quintile for Apo B (fracture: HR 0.85 [0.81, 0.89]”
1 of its findings points the other way.
- 12 independent labs in 6 countries
- 1 finding against
- Funders: UKRI | Medical Research Council and others
- 5 of 16 findings with company ties
- Humans20
What did studies of apolipoprotein B find?
3Studies of apolipoprotein B measured 3 outcomes; the most studied are presbycusis (1 study), healthspan (1) and global cerebral amyloid-beta deposition (1).
Presbycusis
no changein humans1OR 0.979
1 study
Presbycusis
no changein humans1OR 0.979
Apolipoprotein B was not clearly linked with presbycusis in humans (Mendelian randomization, five methods) (OR 0.979, p = .786).
“APOBL OR = 0.979, p = .786”
HumansMendelian randomization, five methods
Hearing research
Healthspan
downin humans1
1 study
Healthspan
downin humans1
Apolipoprotein B is linked with worse healthspan in humans.
“higher levels of APOB and LDL shorten healthspan in humans”
Humans
Communications biology
Global cerebral amyloid-beta deposition
no changein humans1
1 study
Global cerebral amyloid-beta deposition
no changein humans1
Apolipoprotein B was not clearly linked with global cerebral amyloid-beta deposition in humans after controlling for serum triglycerides.
“but the significance disappeared after controlling serum triglycerides level”
Humansafter controlling for serum triglyceridesbrainn = 59
Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
What is apolipoprotein B linked with?
12Studies link apolipoprotein B with 12 measures, most often amyotrophic lateral sclerosis (2 studies), retinal arteriosclerosis (1) and aortic aneurysm (1).
Amyotrophic lateral sclerosis
upin humans1mixedin humans1
2 studies
Amyotrophic lateral sclerosis
upin humans1mixedin humans1
Apolipoprotein B is linked with a higher risk of amyotrophic lateral sclerosis in humans (Mendelian randomization analysis).
“MR revealed causal associations between elevated low-density lipoprotein cholesterol, apolipoprotein B, systolic blood pressure, and increased ALS risk.”
HumansMendelian randomization analysis
NPJ biofilms and microbiomes
Apolipoprotein B is associated with amyotrophic lateral sclerosis in humans (two-sample Mendelian randomization).
“apolipoprotein B, systolic blood pressure, and forced expiratory volume in 1 s (FEV1) with ALS”
Humanstwo-sample Mendelian randomization
Ageing research reviews
Retinal arteriosclerosis
upin humans1OR 1.12
1 study
Retinal arteriosclerosis
upin humans1OR 1.12
Apolipoprotein B is associated with retinal arteriosclerosis in humans (OR 1.12 per 1-SD increase, 95% CI 1.01-1.24).
“both ApoB (per 1-SD increase: OR 1.12, 95% CI 1.01-1.24) and ApoB/ApoA1 ratio (per 1-SD increase: OR 1.14, 95% CI 1.03-1.27) remained independently associated with retinal arteriosclerosis”
Humansfully adjusted models for demographic, lifestyle, clinical and laboratory confounders; per 1-SD increase
Association of the apolipoproteins with retinal arteriosclerosis in a health examination population
Frontiers in cardiovascular medicine
Aortic aneurysm
upin humans1OR 1.443
1 study
Aortic aneurysm
upin humans1OR 1.443
Apolipoprotein B is linked with a higher risk of aortic aneurysm in humans (univariable Mendelian randomization, IVW) (IVW OR 1.443 (95% CI 1.273-1.637)).
“ApoB is significantly associated with aortic aneurysm (IVW odds ratio (OR) = 1.443, 95 % confidence interval (CI) = 1.273-1.637, p < 0.001)”
Humansunivariable Mendelian randomization, IVW
Kardiologiia
Bone fracture
downin humans1HR 0.85
1 study
Bone fracture
downin humans1HR 0.85
Apolipoprotein B is linked with a lower risk of bone fracture in humans (highest quintile) (HR 0.85 (95% CI 0.81-0.89)).
“Conversely, those in the highest quintile for Apo B (fracture: HR 0.85 [0.81, 0.89]”
Humanshighest quintile
Journal of cachexia, sarcopenia and muscle
Alzheimer's disease
upin humans1
1 study
Alzheimer's disease
upin humans1
Apolipoprotein B is linked with a higher risk of Alzheimer's disease in humans.
“we provide preliminary evidence that APOB increases risk for Alzheimer's disease”
Humans
Communications biology
Telomere length
upin humans1
1 study
Telomere length
upin humans1
Apolipoprotein B is associated with telomere length in humans (univariable Mendelian randomization; not seen in multivariable MR).
“The uvMR analysis indicated that an increase in MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and triglycerides (TG) was associated with an increase in TL.”
Humansunivariable Mendelian randomization; not seen in multivariable MR
Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study
Nutrients
Dementia
upin humans1HR 1.12
1 study
Dementia
upin humans1HR 1.12
Apolipoprotein B is linked with a higher risk of dementia in humans (highest versus lowest quarter) (HR 1.12 [1.01, 1.24]).
“the highest quarter of ApoB was associated with greater risk”
Humanshighest versus lowest quarter
EClinicalMedicine
Type 2 diabetes
upin humans1OR 2
1 study
Type 2 diabetes
upin humans1OR 2
Apolipoprotein B is linked with a higher risk of type 2 diabetes in humans (OR 2·32 per 1 SD higher apoB (95% CI 1·49-3·61)).
“which identified apoB to increase (OR 2·32 per 1 SD higher apoB, 95% CI 1·49-3·61)”
Humanstwo-sample multivariable mendelian randomization, adjusting for LDL cholesterol and triglycerides
The lancet. Healthy longevity
Stroke
upin humans1
1 study
Stroke
upin humans1
Apolipoprotein B is linked with a higher risk of stroke in humans (univariable mendelian randomization, mothers).
“and a higher risk of stroke in mothers”
Humansunivariable mendelian randomization, mothersfemales
The lancet. Healthy longevity
Heart disease
upin humans1
1 study
Heart disease
upin humans1
Apolipoprotein B is linked with a higher risk of heart disease in humans (univariable mendelian randomization, all first-degree relatives).
“Genetically elevated apoB caused higher risks of heart disease in all first-degree relatives”
Humansunivariable mendelian randomization, all first-degree relatives
The lancet. Healthy longevity