Hdl cholesterol
Hdl cholesterol has been studied in 8 papers since 2022: 7 observational studies in people, 1 review; 2 in the past year. The newest paper, May 23, 2026: “Associations between lipid parameters and incident cardio-renal-metabolic multimorbidity: The Tehran Lipid and Glucose Study”.
8 papers study it7 findingsUpdated
See all 8 papers on hdl cholesterol
At a glance
The findings reach people, from one lab or study. 6 independent labs in 4 countries.
“HDL-C (fracture: HR 1.27 [1.20, 1.34]; osteoporosis: HR 1.31 [1.18, 1.46])”
None of its findings points the other way.
- 6 independent labs in 4 countries
- Funders: Innovation and Technology Commission - Hong Kong and 7 more
- 2 of 7 findings with company ties
- Humans7
What did studies of hdl cholesterol find?
3Studies of hdl cholesterol measured 3 outcomes; the most studied are presbycusis (1 study), heel bone mineral density (1) and serum BACE1 activity (1).
Presbycusis
no changein humans1OR 0.998
1 study
Presbycusis
no changein humans1OR 0.998
Hdl cholesterol was not clearly linked with presbycusis in humans (Mendelian randomization, five methods) (OR 0.998, p = .979).
“HDL OR = 0.998, p = .979”
HumansMendelian randomization, five methods
Hearing research
Heel bone mineral density
downin humans1OR 0.9548
1 study
Heel bone mineral density
downin humans1OR 0.9548
Hdl cholesterol is linked with lower heel bone mineral density in humans (OR 0.9548, p = 1.25E-05).
“HDL-C had a negative causal association with heel BMD (p = 1.25E-05, OR = 0.9548)”
Humans
Calcified tissue international
Serum BACE1 activity
downin humans1
1 study
Serum BACE1 activity
downin humans1
Hdl cholesterol is linked with lower serum BACE1 activity in humans (β=-0.168).
“high density lipoprotein-cholesterol (HDL-C) (β=-0.168, p<0.0001)”
Humans
The journal of prevention of Alzheimer's disease
What is hdl cholesterol linked with?
4Studies link hdl cholesterol with 4 measures, most often cardio-renal-metabolic multimorbidity (1 study), calcific aortic valve stenosis (1) and osteoporosis (1).
Cardio-renal-metabolic multimorbidity
downin humans1
1 study
Cardio-renal-metabolic multimorbidity
downin humans1
Hdl cholesterol is linked with a lower risk of cardio-renal-metabolic multimorbidity in humans (before adjustment for metabolic risk factors; not after adjustment) (17% lower risk (95% CI 0.73–0.93)).
“HDL-C was associated with a 17% lower risk (95% CI: 0.73-0.93); however, not after adjustment for metabolic risk factors.”
Humansbefore adjustment for metabolic risk factors; not after adjustmentmedian follow-up 15.4 yearsn = 5,721
Nutrition, metabolism, and cardiovascular diseases : NMCD
Calcific aortic valve stenosis
downin humans1OR 0.9
1 study
Calcific aortic valve stenosis
downin humans1OR 0.9
Hdl cholesterol is linked with a lower risk of calcific aortic valve stenosis in humans (two-sample Mendelian randomization using GWAS summary statistics) (OR = 0.9, 95%CI = 0.82–0.99).
“high-density lipoprotein (HDL-C, p = 0.002, OR = 0.9, 95%CI = 0.82–0.99)”
Humanstwo-sample Mendelian randomization using GWAS summary statistics
Journal of cardiothoracic surgery
Osteoporosis
upin humans1HR 1.31
1 study
Osteoporosis
upin humans1HR 1.31
Hdl cholesterol is linked with a higher risk of osteoporosis in humans (highest quintile) (HR 1.31 (95% CI 1.18-1.46)).
“HDL-C (fracture: HR 1.27 [1.20, 1.34]; osteoporosis: HR 1.31 [1.18, 1.46])”
Humanshighest quintile
Journal of cachexia, sarcopenia and muscle
Bone fracture
upin humans1HR 1.27
1 study
Bone fracture
upin humans1HR 1.27
Hdl cholesterol is linked with a higher risk of bone fracture in humans (highest quintile) (HR 1.27 (95% CI 1.20-1.34)).
“HDL-C (fracture: HR 1.27 [1.20, 1.34]; osteoporosis: HR 1.31 [1.18, 1.46])”
Humanshighest quintile
Journal of cachexia, sarcopenia and muscle