TRIM72

1. TRIM72 decreases membrane disruption.

   “mediator of sarcolemmal membrane repair, may also function as a stress-responsive regulator that stabilizes the early activation environment”

   Reviewskeletal muscle

   MG53 in Early Skeletal Muscle Stem Cell Activation: Implications for Aged Muscle Regeneration

   Cells·Mar 5, 2026

1. TRIM72 improves muscle stem cell activation.

   “MG53 is proposed to facilitate activation by mitigating stress-associated membrane disruption and maintaining programmatic coordination under age-related physiological constraints”

   Reviewunder age-related physiological constraintsskeletal muscle

   MG53 in Early Skeletal Muscle Stem Cell Activation: Implications for Aged Muscle Regeneration

   Cells·Mar 5, 2026

1. TRIM72 is required for plasma membrane repair in cells.

   “which could be blocked by siRNA-TRIM72”

   Cellsin membrane repair by MOTS-c

   Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane

   Theranostics·Aug 19, 2024

1. TRIM72 predicts pTau181/ in humans (β=3.751, p = 0.008).

   “TRI72 (β=3.751, p = 0.008) and TREM2 (β=‐3.000, p = 0.022) which showed the strongest associations with the progression of pTau181”

   Humanslongitudinal association

   Proteomic Signatures of Dual Cognitive and Mobility Decline in Older Adults

   AAIC 2025 abstract·Dec 24, 2025

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