TP53
GeneHomo sapiens6 papersHGNC 11998NCBI Gene 7157Taxon 9606
- Animals2
- Cells3
Latest
9Pathogenic modulators of cellular senescence
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chinese journal of natural medicines · Wang Y et al.
Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies
Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications
Telomeres in Aging: Links to Clonal Hematopoiesis, Cardiovascular Disease, and Cancer
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Research Square · Liu M et al.
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C
FUNDC1 protects skin against UVA damage through mitophagy and P53 stability
Researchers identified a molecular pathway where FUNDC1 preserves mitochondrial quality and works with BAZ1B to regulate P53 during skin photoaging.
Antioxidants (Basel, Switzerland) · Zhang C et al.
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling
Unlike human and mouse cells, blind mole-rat stem cells maintained viability and differentiation after carcinogen exposure by preserving protective gene pathways.
Stem cells (Dayton, Ohio) · Unver N et al.