TLR2
Gene3 papers5 findingsHGNC 11848NCBI Gene 7097Taxon 9606
- Animals2
- Cells1
Effects
5pSer129 alpha-synuclein
upin mouse cells1
1 study
pSer129 alpha-synuclein
upin mouse cells1
TLR2 increases pSer129 alpha-synuclein in mouse cells.
Cellsin STC-1 cells
TLR2 Regulates α-Synuclein Phosphorylation and Release in an Enteroendocrine Cell Model · Molecular neurobiology · 16 Sep 2026
Cellular uptake of alpha-synuclein fibrils
upin mouse cells1
1 study
Cellular uptake of alpha-synuclein fibrils
upin mouse cells1
TLR2 increases cellular uptake of alpha-synuclein fibrils in mouse cells.
Cellsin STC-1 cells
TLR2 Regulates α-Synuclein Phosphorylation and Release in an Enteroendocrine Cell Model · Molecular neurobiology · 16 Sep 2026
Islet fibrosis
upin mice1
1 study
Islet fibrosis
upin mice1
TLR2 increases islet fibrosis in mice.
Animalsshown by knockoutpancreasmales
Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets · Immunity & ageing : I & A · 12 Sep 2026
Beta-cell mass expansion
upin mice1
1 study
Beta-cell mass expansion
upin mice1
TLR2 increases beta-cell mass expansion in mice.
Animalsshown by knockoutpancreasmales
Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets · Immunity & ageing : I & A · 12 Sep 2026
Islet hypertrophy
upin mice1
1 study
Islet hypertrophy
upin mice1
TLR2 increases islet hypertrophy in mice.
Animalsshown by knockoutpancreasmales
Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets · Immunity & ageing : I & A · 12 Sep 2026
Funding
National Institute on AgingUS$1.1m2 grants since 2022
Sialylation of TLR2 Induces Osteoclast Fusion and Th 17 differentiation During Aging
National Institute on AgingJohns Hopkins UniversityUS$473.1k2022–2027
Endothelial TLR2/4 signaling in sex dimorphism of pathological angiogenesis and aging
National Institute on AgingCleveland Clinic Lerner Com-cwruUS$659.3k2025–2030