SQSTM1
GeneHomo sapiens2 papers1 findingHGNC 11280NCBI Gene 8878Taxon 9606
- Cells2
Effects
1Autophagy
mediatesin reviews1
1 study
Autophagy
mediatesin reviews1
SQSTM1 mediates autophagy.
Review
Sequestosome 1 (SQSTM1/p62) at the nexus of genome integrity maintenance, proteostasis regulation and organellar homeostasis · Biological chemistry · 28 Sep 2026
Latest
5Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Frontiers in pharmacology · Yang K et al.
Neuroinflammation and Autophagy in Neurodegeneration: Cellular Mechanisms and Therapeutic Strategies
ReviewCNS & neurological disorders drug targets
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.
The EMBO journal · Kaypee S et al.