OPA1

1. OPA1 inhibits cGAS–STING signalling in mice.

   AnimalsOPA1 deficiency activates mtDNA-cGAS/STING pathway

   Macrophage OPA1 Prevents Age-Related Metabolic Dysfunction via the mtDNA-STING-STAT6 Pathway · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

cGAS–STING signalling →

1. OPA1 decreases metabolic disease in mice.

   AnimalsOPA1 overexpression

   Macrophage OPA1 Prevents Age-Related Metabolic Dysfunction via the mtDNA-STING-STAT6 Pathway · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Metabolic disease →

1. OPA1 decreases inflammation in mice.

   Animalsin vivo in perivascular macrophagesadipose tissue

   Macrophage OPA1 Prevents Age-Related Metabolic Dysfunction via the mtDNA-STING-STAT6 Pathway · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Inflammation →

1. OPA1 decreases cellular senescence in mouse cells.

   Cellsin M2-polarized macrophages in vitro, shown by OPA1 loss

   Macrophage OPA1 Prevents Age-Related Metabolic Dysfunction via the mtDNA-STING-STAT6 Pathway · ADA Scientific Sessions 2026 abstract · 5 Jun 2026

Cellular senescence →