SOD1 aggregates

1. Rapamycin has no effect on SOD1 aggregates in mice.

   “has no obvious effects on the accumulation of SOD1 aggregates”

   Animalsin SOD1(G93A) mice

   Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis

   Autophagy·Apr 1, 2011

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1. MT1 decreases SOD1 aggregates in mice.

   “decreased level of SOD1 aggregates within the glial cells of the spinal cord”

   Animalsin SOD1(G93A) micespinal cord

   Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

   Human molecular genetics·Oct 24, 2013

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