METRNL

4 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Human trial1
Animals2

Effects

1

Stem cell differentiation

downin mouse cells1

1 study

METRNL inhibits stem cell differentiation in mouse cells.
“This process subsequently upregulates transcription of the circadian clock gene Cryptochrome 2 (Cry2), thereby suppressing osteoblast differentiation.”
Cells
An Integrated Approach Reveals the Pre-Osteoblast-Driven Metrnl Synergizes With Circadian Genes to Inhibit Osteogenesis
Frontiers in bioscience (Landmark edition)24 Jun 2026

More on Stem cell differentiation

Associations

1

Osteoporosis

downin humans1

1 study

METRNL is associated with osteoporosis in humans.
“Clinically, Metrnl expression was significantly diminished in bone marrow samples from postmenopausal women with OP, suggesting potential relevance to human disease.”
Humansin postmenopausal womenbone marrowfemales
An Integrated Approach Reveals the Pre-Osteoblast-Driven Metrnl Synergizes With Circadian Genes to Inhibit Osteogenesis
Frontiers in bioscience (Landmark edition)24 Jun 2026

More on Osteoporosis

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