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CK2

There are 5 papers on CK2 in aging research: none in people yet, 1 in animals, 3 in cells, 1 review.

Gene

5 papers study it5 findings

Taxon

See all 5 papers on CK2

At a glance

The findings reach cells, none yet in people. 2 independent labs in 2 countries.

None of its findings points the other way.

Cells: a single group. Worms or flies, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: National Research Foundation of Korea and 3 more
  • Model organisms1
  • Cells3

Interventions

2

Quercetin

downin reviews1

1 study

  1. Quercetin inhibits CK2 (high nanomolar concentrations).

    “certain flavonols, notably quercetin, can inhibit CK2 in high nanomolar concentrations that may be clinically relevant”

    Reviewhigh nanomolar concentrations

    Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass

    International journal of molecular sciences

More on Quercetin

Spermidine

upin mouse cells1

1 study

  1. Spermidine activates CK2 in mouse cells.

    “Permidine treatment activates CK2 by releasing the interaction between lamin A and CK2”

    Cellspermidine

    Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model

    Science advances

More on Spermidine

Effects

3

RelA/p65 K310 acetylation

downin human cells1

1 study

  1. CK2 decreases RelA/p65 K310 acetylation in human cells (shown by knockdown).

    “increased the acetylation of lysine 310 on RelA/p65”

    Cellsshown by knockdown

    CK2 Down-Regulation Increases the Expression of Senescence-Associated Secretory Phenotype Factors through NF-κB Activation

    International journal of molecular sciences

Senescence-associated secretory phenotype (SASP)

downin human cells1

1 study

  1. CK2 decreases senescence-associated secretory phenotype (SASP) in human cells (shown by knockdown in MCF-7 and HCT116 cells).

    “CK2 down-regulation induced the expression of SASP factors, including interleukin (IL)-1β, IL-6, and matrix metalloproteinase (MMP) 3”

    Cellsshown by knockdown in MCF-7 and HCT116 cells

    CK2 Down-Regulation Increases the Expression of Senescence-Associated Secretory Phenotype Factors through NF-κB Activation

    International journal of molecular sciences

More on Senescence-associated secretory phenotype (SASP)

SIRT1PROTEIN

downin human cells1

1 study

  1. CK2 decreases SIRT1PROTEIN in human cells (CK2 downregulation).

    “CK2 downregulation destabilized SIRT1 protein via an ubiquitin-proteasome pathway in human cells”

    CellsCK2 downregulation

    Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging

    BMB reports

More on SIRT1PROTEIN

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